In 2017, the American Society of Transplantation (AST) and the Transplantation and Immunology Research Network (TIRN) facilitated providing $460,000 in research money to investigators in the field of transplantation. TIRN provides both career development grants for young investigators and research funding in specific areas along with outside organizations.
AST TIRN/Astellas Clinical Science Faculty Development Research Grant
Wayne M Tsuang, MD, MHS, Cleveland Clinic
Dr. Tsuang was selected for this grant for his research project titled “Improving Access to Lung Transplant with Broader Geographic Sharing.” His efforts will focus on determining how changing the Donor Service Areas (DSAs) would impact those in need of lung transplants.
AST TIRN Basic Science Faculty Development Research Grant
Anne D. Cherry, MD, Duke University
Dr. Cherry’s research project is titled “Interface of Mitochondrial Dysfunction and Immune Activation in Heterotopic Mouse Heart Transplant.” Through her research, she aims to reduce primary graft dysfunction (PGD) in transplant patients.
AST TIRN/Bristol Myers Squibb Basic Science Fellowship Research Grant
Scott Krummey, MD, PhD, Emory University School of Medicine
Dr. Krummey was selected to receive this grant for his research project, “Dual Coinhibitor Receptor Signaling to Restrain Graft-Specific Memory T-Helper 17 Cell Responses.” The research explores the potential of differentially manipulating CD28/CTLA-4 signals along with the PD-1 pathway to potently restrain human allogeneic CD4+ Th17 responses.
AST TIRN Translational Science Fellowship Research Grant
Mark Snyder, MD, Columbia University Medical Center
Dr. Snyder was awarded this grant for his research project, “Role of tissue resident memory T cells in both acute and chronic rejection following lung transplantation.” This research aims to define the dynamics of how donor and recipient Trm cells are maintained in the lung following transplantation, and to investigate the function and specificity of Trm cells to common viral pathogens of the lung following transplant.
AST TIRN/Wood MacMillan Charitable Fund Allied Health Professional Research Grant
Jennifer Trofe-Clark, PharmD, BCPS, FCCP, FAST, Perelman School of Medicine
Dr. Trofe-Clark’s research project is entitled “Assessments of Literacy, Cognitive Function and Medication Knowledge in Renal Transplant Recipients in the Ambulatory Care Setting.” The research funding will assist her in reaching her aim to improve medication literacy and adherence in renal transplant recipients.
AST TIRN/Astellas Research Grant
David Rothstein, MD, University of Pittsburgh
Dr. Rothstein’s research project, “Transitional-1 (T1) B cell cytokine ratio as a prognostic biomarker for clinical course in renal transplantation that guides therapeutic intervention” was awarded this grant. The research focuses on transitional-1 (T1) B cell cytokine as a prognostic biomarker, as current clinical markers cannot sufficiently predict outcomes and identify individuals needing a preemptive increase immunosuppression.
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